Born in Ghent, Belgium on June 24, 1987, Trixie Whitley moved to New York with her mother Hélène Gevaert when she was just a year old, where her father, musician Chris Whitley lived. Even as a toddler, she was immersed in music and the arts, spending time in some of the world's most renowned studios, including Electric Lady Studios. Her early years were split between Ghent and New York City. Trixie began playing the drums when she was 10. At 11, she was touring Europe with several theater companies, and, at the age of 14, with the dance company, "Les Ballets C de la B," as an actor, singer, dancer, and musician. During this same period, Trixie also became known as the youngest resident DJ in Europe, embraced by Belgium's Museum of Modern Art and spinning at raves, festivals, and parties in Brussels, Paris, New York, and Amsterdam.
After her time with Les Ballets C de la B and other performing arts collectives in Europe, she quit school to move back to New York City at age 17. Working odd jobs in Brooklyn and Queens, she started to perform her own music in clubs throughout the city.